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African American Men and Prostate Cancer A recent study offers a bit of good news for African American men and their greater risk for getting -- and dying from -- prostate cancer. A new Wayne State University study shows the survival gap may be narrowing between African-Americans and Caucasians who had their prostate surgically removed after suffering from prostate cancer. The researchers discovered that while white men were more likely than blacks to remain free from cancer from 1990 to 1995, the gap between the races narrowed from 1996 to 1999. During the earlier period, cancer was diagnosed before it spread outside of the prostate in 38 percent of African-Americans and 48 percent of whites. From 1996 to 1999, however, the rate of prostate-confined cancer was 54 percent in blacks and 62 percent in whites. Relapse occurs most often during the first three years after surgery. One of the researchers, Dr. Fernando Bianco, a WSU urologist, says earlier detection of prostate cancer helps explain the decline in relapse rates because more cases were caught at an earlier stage before the cancer spread outside the prostate. He believes this is due to prostatic-specific-antigen (PSA) testing that measures a protein made by the prostate and can indicate prostate cancer. Not Created Equal African-American males have the highest incidence of prostate cancer in the world and suffer two to three times higher mortality than Caucasian men. For every 100,000 African-American men, for example, about 180 will have prostate cancer this year, and more than 50 will die from the disease. While diet, quality of care, and other environmental and behavioral factors are suspected of contributing to the higher rate of prostate cancer in African-Americans, many researchers believe genetic factors play a large role. These factors may be associated with a higher tendency for tumor progression, recurrence and metastasis in African-American compared to Caucasian men. Scientists are just beginning to study the role of inherited factors. Recently, scientists at the National Human Genome Research Institute (NHGRI) mapped the location of a gene associated with increased risk of prostate cancer. They estimate alterations in this gene, called HPC-1, are responsible for at lease one-third of the prostate cancer that runs in families. Approximately 1 in every 500 men is believed to possess an altered version of HPC-1. Initial studies suggest that HPC-1 may play a particularly prominent role in early onset familial prostate cancer among African-Americans, but only a few such families have been analyzed. Better Test for African Americans Peter Littrup, M.D., a radiologist at the Barbara Ann Karmanos Cancer Institute, recommends African-American men have a modified PSA test that incorporates prostate size or density, if their PSA level is elevated. Littrup says the new test -- called color doppler ultrasound-guided biopsy (CDUGB) -- is more accurate in African-American men than other men. The CDUGB test, when performed immediately following the detection of a PSA abnormality, may improve the diagnosis of prostate cancer for some men. Typically, men with mildly elevated PSA levels are advised to wait for six months to a year, then have a second PSA test, rather than having an immediate biopsy. "Because prostate cancer is twice as common and three times as deadly in African-American men, immediate biopsy is recommended for African-Americans and others at high risk, instead of watchful waiting," says Dr. Littrup. "Cancers caught in an earlier stage may lead to better cure rates and save more lives."
Fatherless Families Damages Boy's Self-esteem Living
in a fatherless family damages a black boy's self-esteem, says an American
study released recently.
High
Blood Pressure Rates Vary Widely Among Blacks Their study of national survey data found that when it comes to high blood pressure, African Americans could be separated into 12 "distinct subgroups" whose rates of the disease range from a low of 11% to a high of 78%. Among the nearly 3,400 study participants, those in the two highest risk groups were older than 45, mostly overweight or obese, often physically inactive and frequently had diabetes. In fact, all of those in the top risk group had diabetes, according to findings published in the October issue of the journal Preventive Medicine. Both high blood pressure and diabetes, which often occur together, are major risk factors for heart disease, stroke and kidney disease. The researchers, led by Dr. Rakale Collins of Morehouse School of Medicine in Atlanta, Georgia, also found that men, younger individuals and those who infrequently saw a doctor were less likely to have their high blood pressure under control with medication. "This study has clearly identified those African American subgroups in greatest need of intervention programs," write Collins and colleague Dr. Marilyn A. Winkleby. For example, they point out, among the factors most strongly tied to high blood pressure was excess weight--in the two highest risk groups, 80% and 100% of participants were overweight or obese. A majority of these participants also had not finished high school. Collins and Winkleby note that the way health information is communicated, as well as the cost of medical care and drugs, need to be addressed in order to serve those at greatest risk of high blood pressure. The researchers also point out that even in the study group with the lowest rate of high blood pressure--those who were younger than 37 and had a relatively lower weight overall--there were substantial risk factors for future high blood pressure. Half were overweight or obese, and 40% smoked. "These risk factors must be addressed in a primary prevention effort," the study authors write, "or they will become a problem" as these individuals grow older.
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